The following studies are currently underway in which you might be interested in participating:
The Scottish Intracranial Vascular Malformation Study (SIVMS)
Objectives of the study
To organize and conduct the first large, observational, prospective, population-based study of IVMs by establishing a collaborative National Disease Register for IVMs in Scotland
To establish the incidence and prevalence of IVMs using this population-based design
To secure complete, long-term prospective follow-up of a growing cohort of patients newly-diagnosed with IVMs in order to:
establish prognosis
observe the outcome of treatment
To develop prognostic models for people with IVMs
To form the foundation for related studies:
investigate the genetic contribution to the etiology, angioarchitecture, prognosis and response to treatment of IVMs
assess observer variability amongst experienced Neuroradiologists in the interpretation of angiograms of AVMs
form a methodological basis for a planned AVM disease register in the United Kingdom and a planned population-based study in Western Australia, which could enable future collaboration
Inclusion criteria
Age 16 years or over at the time of diagnosis
Permanently resident in Scotland at the time of diagnosis
Date of diagnosis (by imaging or histology) after 1st January 1999
Any of the principal sub-types of IVM:
Arteriovenous malformation of the brain (AVM)
Cavernous malformation (CM)
Venous malformation (VM) including asymptomatic venous anomalies
Dural arteriovenous malformation (DAVM) including carotid-cavernous fistulae
Exclusion Criteria
Failure to meet all the inclusion criteria
Incorrect diagnosis of an IVM
Capillary malformation/telangiectasis
Vein of Galen malformation
Capillary malformation/telangiectasis
Spinal vascular malformation
Bramwell Dott Building
Department of Clinical Neurosciences
Western General HospitalS NHS Trust
Crewe Road, Edinburgh, Scotland
EH4 2XU
